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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

For: Well-received by both audiences and critics, it tells a crucial slice of history.
a不+dama征服+ant→不可征服的→坚定的,坚固的

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

I will be yours forever!我永远属于你!
Comic skit “Dance If You Like” (Cai Ming and Pan Changjiang)

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

The first view is that the price is inherently cyclical. What has come down must go back up again and the deeper the trough the higher the next mountain.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

His footballing rival Lionel Messi - who the 31-year-old beat to be crowned the World Player of the Year in January - was second on the list, taking home pound 56 million in 2015/16.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.
In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.在这欢乐的时节给你我最真的祝福和亲切的思念,愿你今年的新年比往年更璀璨。
Historians now hope to dispel some of the myths about Richard, publicising evidence to refute claims that he killed the two young princes and focusing on what he achieved in his brief two-year reign, including the establishment of a system of bail and legal aid.
The show was a potent reminder that the sexual revolution and women entering the work force and the rise of consumerism and the Age of Aquarius (all that) had a dark side, and claimed their own victims. That’s part of why it was such a powerful show.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.
What would he try for his solo move: "Sweet Creature" and "Ever Since New York" are intimate acoustic ballads; while "Kiwi" lets him strut his Oasis-style self at top volume. "Two Ghosts" is a break-up lament .
历届“邦女郎”性感比拼
“I think the best way to engage young people in the process is to win,” he says.

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 广州“自愿不购买社保”条款无效
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

企业能否最终摆脱谨慎情绪?

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

They came together in resurgent nationalism and xenophobia.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Major areas of work for 2017
8. Employment futures weak as pensions drain states, municipalities

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

7.洗牙师
Bigger isn’t always better.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

如果你在工作时间去寻找其他的工作岗位,很明显,你想要辞掉你的工作。去找一份新工作吧,如果找到,就换吧。
“有个人离职时给全体员工群发了一封邮件。”

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

冲击奖项:最佳电影奖和最佳导演奖,让人意外的是,诺兰从未获得过奥斯卡奖提名。
Guangzhou and Shenzhen, benefiting from balanced development, took first and second place respectively in the rankings. Hangzhou ranked third, owing to its technological advantages. Wuhan, which had achieved a good balance between development and costs, was in fourth place, followed by Nanjing with its quality culture and lifestyle.
7. Corrections officer
自2007年4月以来,全球最具价值品牌100强的品牌价值增长106%。同期标准普尔500指数(S&P 500)和MSCI明晟全球指数(MSCI world index)分别上涨61%和21%。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

单词administration 联想记忆:

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

……被要求向面试官简单介绍自己,结果她没有什么可说的。
勒布朗·詹姆斯

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

节目37 相声《东西南北大拜年》,赵炎 逗笑 逗乐 大新等

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Hope all your New Year dreams come true!

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 租房如何避开“隐形杀手”?
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

单词continuous 联想记忆:
在第一部掌上移动设备发明之前,自拍杆已经问世。自拍杆其实是由一个日本男人上田宏在20世纪80年代发明的。上田宏是美能达相机公司的摄影师,他发明这个自拍杆,是因为他和妻子在欧洲旅行时无法自拍合照。(当时,他叫一个男孩帮他们拍照,那个男孩却拿着相机跑了。)
美国谷歌搜索2017排名前十
中国品牌上榜主要是挤掉了欧洲企业,这表明,经济实力正向东方转移。只有一家印度品牌登上百强榜:HDFC Bank。过去几年,俄罗斯、墨西哥和巴西品牌纷纷落榜,这残酷反映出这些新兴市场的命运正发生变化。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

顾名思义,这个真人秀节目还专门拍摄学生们的母亲,展现母亲如何教育孩子与他人竞争。
Two bedrooms are on the second floor, including the master, which is part of a suite with a fireplace, a walk-in closet and a balcony overlooking the bay. An office down the hall also opens to the balcony. The other bedrooms are on the third floor. One overlooks the bay through the pediment’s fan window.
1、死侍
美联储给当下的新兴市场带来了何种风险?克普克表示,最大的风险之一是,它可能“落在曲线后面”,延误加息太久。相比正确路径,这将导致最终的加息幅度大得出乎意料,最终的利率绝对水平也更高。
2016年的欧洲杯足球赛,俄罗斯与英国球迷因其粗鲁及流氓行为一直占据新闻头条。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

10、日本8.5级地震
“‘降温’措施(是)影响香港(住宅)地产市场的最重要问题,”莱坊估价主管林浩文(Thomas Lam)说,“这正是过去两三年里所有大型机构的方案都在关注写字楼市场的原因。”

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

“对新兴市场来说,今年是惨淡的一年,”瑞士基金管理公司GAM的新兴市场投资总监保罗麦克纳马拉(Paul McNamara)表示。“资产不断流失,而没有人肯定下周这个时候市场会是什么样子。”

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

It is up to other institutions — notably, Congress, courts and media — and the citizens at large now to do so.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

"At a time when the world seems defined by division, storytellers bring us together as one," AFI president and CEO Bob Gazzale said Thursday in a statement. "AFI Awards is honored to celebrate this community of artists who challenge and inspire us, entertain and enlighten us - ultimately reminding us of our common heartbeat."
Over the summer, the bubble in the Chinese stock markets burst, wiping out trillions of dollars in valuation. Despite extensive efforts to contain the plunge, the Shanghai Composite Index had declined 43 percent on Aug. 26 since its peak on June 12.
In the US, he adds, ETFs emerged into a market where there were lots of registered investment advisers incentivised to use lower-cost products for their clients.
3.5 促进农业稳定发展和农民持续增收

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

4. 欧佩克的下一步行动。说到去年的油价暴跌,石油输出国组织(OPEC)起了很大作用(或者说要承担很大责任)。虽然许多评论人士都说欧佩克保持原油产量不变无关紧要,然而,仅油价在该组织11月份会议过后出现暴跌这一事实便充分证明了该组织对油价走势的影响力。目前,欧佩克——更确切地说是沙特——仍在坚持己见,毫无下调生产配额的迹象。2015年这一情况是否会得以延续,仍有待观察。
创造就业和削减赤字将成为华盛顿在2010年选举之年的孪生执念。不过,这两样一个都成不了现实。
May its blessings lead into a wonderful year for you and all whom you hold dear.祝福你及你所爱的人新的一年中万事如意。
strain

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

adj. 可能的,潜在的
But it's the best pay on offer for a major world leader.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

这位工作人员说道:“她注册时说自己姓韩,也不是像媒体上报道的姓苏。”
“This growth is further backed by Video Editing making an appearance at number 3 on the list with a 19% increase,” the report states, “as video content becomes one of the initial draws and call to actions for most customer-focused websites. Heavy video marketing through social media also increases this demand.”
他补充说道:“我很兴奋能有机会重返中国,并享受这个国家的文化以及把NBA现场比赛的激动直接带给中国球迷。”
今年世界卫生组织宣布H1N1型流感为全球性传染病。庆幸的是,这种病毒远没有人们最初想的那样危险,而最新面世的疫苗似乎已经平息了那弥留在人们心头久久不能散去的恐惧。
3. Jia Junpeng, your mom wants you to go home for dinner.”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 家具回收价太低 市民换新不容易
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

多名网友爆料称,周六日研究生入学考试开考前,部分试题和答案就已经提前被公布了。
'In the meantime, the U.S. continues to grow its own domestic production both in oil and gas. I think, for us, it's less about where the actual price is going--it's more about how much more growth is left in North American oil sands, shale gas, shale oil,' as well as shale exploration elsewhere, he said.
上海社会科学院的专家周海旺告诉环球时报:“上海自2014以来就采取了一系列强硬措施,包括改造城中村和规范群租来控制人口增长。”

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 抑制非理性学区平房交易
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

intel在…中间+lig选择,收集+ence→从中选出好的→智力;聪明
《出租车司机》被誉为历史上最伟大的电影之一,讲述了一名沮丧的前海军陆战队员,在被爱慕的女子拒绝后,试图暗杀参议员的故事。名义上的出租车司机崔维斯·拜寇,生活混乱,充斥着毒贩和妓女,但他的故事从来不是不现实的幻想。相反,它揭示了一个人差点成为成为枪手的真实预警。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

虽然总统那晚险胜,此次相逢与前两次辩论相比是诚恳且基本上平安无事的,不太可能对选举结果产生多大的影响。
《敦刻尔克》
该排名的编辑菲尔·巴蒂称:“在近几年取得重大进展之后,中国在全球排名榜上的持续增长似乎已经停滞。这些新数据显示,新兴力量要打入传统的全球名校阶层是多么困难。”

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 收紧贷款别让刚需躺枪
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

7. “飞翔莲花”(Flying Lotus),《你死了》(You’re Dead), Warp。新融合乐绝不会对旧融合乐说抱歉,这只是升级而已。身为制作人的“飞翔莲花”既注重延续性,也注重破坏、模糊之美与跳跃剪辑的喧闹。他对死亡的组曲式沉思为不虔敬的智慧留出空间,《永远不能抓住我》(Never Catch Me)这首歌的歌词由肯德里克·拉玛(Kendrick Lamar)创作,堪称年度最佳。
adj. 有毒的
近些年来,细菌感染卷土重来,受害者达到了自1960s以来从所未见的最高值,初步确诊者的人数从429跃升至1300多人,从2011年到2017年期间的感染人数翻了两倍不止。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 揽才新政频出 各地发力稳就业
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

单词outrage 联想记忆:

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

随着北京方面采取的资本管制对海外收购交易起到抑制作用,1月份中国企业对海外房地产业的投资额比上年同期下降了84%。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Comic skit “I Want To Be In Spring Festival Gala” (Various artistes)
['k?:p?rit]

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

[?'s?u?ieit]
democratic
在第二轮(重新)谈判不久前结束后,我们真正进入了贸易谈判的技术官僚阶段。
单词institute 联想记忆:

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

The report said."It is important to balance economic measures of societal progress with measures of subjective well-being to ensure that economic progress leads to broad improvements across life domains, not just greater economic capacity," the report said.
“尼克是一位优秀的产品思想家,”雅虎移动与新兴产品高级副总裁亚当卡恩(Adam Cahan)说,“他的确代表了他在思索的事物和‘移动’真正内涵的跨世代转变。新一代不仅仅是以移动为先,而且是以移动设备为唯一上网工具。这是一种不同的视角。”

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

根据声明,通州新的行政中心将把基础设施升级和生态建设放在首位。北京市政府希望可以提高该地区的教育、医疗、文化事务与产业在内的公共服务发展。
original

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 房地产规划变更监管将加强
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

乔治王子获得满分,因为他对加拿大总理特鲁多傲慢的击掌回了一记冷眼。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

不会。当然,这种情况可能发生,但是只要运气不是太差,梅眼下至少可以确保英国经济不会在2019年因掉落“无协议”悬崖而急剧下滑。2017年12月,“共识预测”(Consensus Forecasts)预测2018年英国将增长1.5%。该机构对日本和意大利的预测值更低,为1.3%。因此英国明年成为G7中经济增长最慢国家的几率应该在四分之一左右。
6.Do All the Work, Plus More
该机构还表示,周二仍有876个岗位无人报名,其中包括上海和西安的铁路警察。
这些担忧给周五开幕、为期两天的G20央行行长和财长会议投下了浓重的阴影。本周国际货币基金组织(IMF)已经警告准备下调其对今年全球增长的预测,称主要经济体需要采取更多举措来刺激增长。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 棚改垃圾 就地消纳
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

The report ranks brands based on financial performance, its influence on customers, and its power to command a premium price or drive company sales.
n. 回答,响应,反应,答复

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

[k?m'plein]
当我想要对一个机会大声喊“No”时,这往往是个信号,提醒我还有一个答案或许该是“Yes”。如此一来,我会深呼吸一下,然后尽量客观地分析现状。
The report notes that China's game developers have been considering subscription models since earlier this year. Among the top 10 games, four are subscription-based titles and two were commercially launched this year, including Shanda Interactive Entertainment Ltd.'s (SNDA) major new title, AION. The Cnzz.com says that a shift to the subscription model would be more likely to create a sense of equity and fairness in the games, because the top players would be those who spend the most time playing, instead of those who spend the most.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

网上的撤稿公告共列出了107篇论文及524位作者,他们几乎都是中国临床肿瘤专家。所涉及的医院都是顶级公立机构。
The Cnzz.com report also discusses the problem of the 'free-to-play' business model that's prevalent in China's online game sector. While many games companies in the U.S., for example, charge subscription fees, most Chinese games utilize the free-to-play model, which allows players to try out a game without paying. The longer players stay in the game, the more likely they will be to pay for in-game items to move up into higher levels of play. But that also means that people who spend the most money are the best performers.
No.4: The 1st Useful Mechanical Pet

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

由于制度是在专制统治下制定的,那么反对派就会被迫反叛或者顺从。
这一现象值得注意。巴西是个多种族国家,黑人占总人口比例位居世界第二,仅低于尼日利亚。在2010年的人口普查中,超过一半的巴西人认为自己是黑人或混血儿。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

The latest list showed that University of Hong Kong ranked third and University of Macao seized the sixth place.
引人注目的是,在首次上榜的9所学校中,亚利桑那州立大学(Arizona State University)的WP凯瑞商学院(WP Carey School of Business)成为首次参与此项排名的美国学校,排在第82位。
Perhaps it will not catch on in the cut-throat world of Wall Street. Some may see an extended absence as an admission that their jobs are expendable, and that colleagues can survive — and perhaps thrive — without them.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 超低能耗建筑将成建设新趋势
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

库迪斯和沃斯在孜孜不倦分析荷兰金融记录的过程中得出了结论,悲观者和乐观者之间真正的区别在于他们是否亲身经历过这样的痛苦过程。库迪斯认为,可以类比的是那些经历过大萧条的人们的行为:这些人在大萧条梦魇过去后的几十年里,一直回避金融风险。
It was unearthed by archaeologists in 2012 and has since been kept at the Yizheng Museum. It is not shown to the public.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Among dozens of small, technology-focused acquisitions, the $3bn purchase of Beats Electronics, the celebrity-endorsed headphones and music streaming service, stands out as Apple’s largest ever deal. The acquisition still bemuses many Apple analysts, but in Jimmy Iovine and Dr Dre, Beats’ founders, Mr Cook has instantly regained credibility with the music industry after years of neglecting the iTunes download store. If Mr Cook is guilty of missing the rapid growth of subscription services such as Spotify, he has moved swiftly to compensate for it — though for a high price.
This move works on multiple fronts for the Thunder. First, Gibson helps fill in for the injured Enes Kanter in the short-term and he brings playoff experience, solid rebounding and hard-nosed defense to a possible postseason matchup with the Spurs or Rockets.
2017年,我国购买了14.1万台工业机器人,同比增长58.1%,然而在购买的机器人中,外资品牌占比近3/4,这表明国产与国外机器人制造商存在的差距仍在扩大。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Yes. With the US Federal Reserve likely to raise interest rates a few times in 2018, trading is likely to be choppy in emerging markets. Sometimes it may feel a bit like a rerun of the 2013 “taper tantrum”. However, average GDP growth will rise to 5 per cent, up from a forecast 4.7 per cent this year. This will mostly be because Russia and Brazil, which have stumbled, will bounce back.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 广州81个房地产项目违规被查
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 建材市场下半年或迎第二春?
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

China Mobile, supply chain rumors are emerging about Apple’s next significant product releases. Digitimes reports that according to “sources from the upstream supply chain, ” Apple is planning to release a 5-inch iPhone 6 “phablet” this coming May and a large tablet in October.
在2010年世界杯中,智利当属最振奋人心的一支队伍,并在最近的温布利比赛中让英格兰队在赛场上四处兜转,不过,如果哥伦比亚队能够融合射手拉达梅尔·法尔考(Radamel Falcao),那么这支队可能会让一两支队伍神伤了。因此,在所有的南美洲球队中,似乎只有厄瓜多尔难以走出小组赛,而其余的所有国家都有能力奋战到后面的阶段。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Ohsumi’s research on autophagy shines a light on ubiquitous diseases such as Parkinson’s and diabetes.
在过去三年里,夏威夷航空公司的航班延误率只有6.92%,几乎是排名第二的阿拉斯加航空公司的一半——这家公司的航班延误率达到11.27%。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

麦肯锡将于3月宣布当选者,预计此人将对麦肯锡的发展方向产生重大影响。一些内部人士倾向于那些在快速增长领域(比如数据分析)具备专长的候选人,而其他人想要一位可以维护公司品牌的传统主义者。
6.不是故事的结局不够好,而是我们对故事要求太多。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

On the sales front, General Motors and Ford F -0.13% lost market share to Chrysler, which leveraged its Jeep brand to previously unimagined heights – and then, metaphorically left its heritage behind when it established legal domicile in the Netherlands and changed its name to FCA US LLC.
007系列电影主题曲第六名:杜兰·杜兰--《雷霆杀机》

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

开发商:Frontier、Microsoft Studios

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

在这两个新指标方面,英国商学院的表现都优于法国商学院。在职业发展方面表现最好的英国商学院——华威商学院(Warwick Business School)在这一指标的总体排名中位居第二,高于法国在这方面表现最好的巴黎高等商学院(HEC Paris) 30个名次。在毕业后首份工作薪资与当下薪资比较方面,英国商学院校友的薪资增幅更大,为62%,法国商学院校友的薪资增幅为45%。然而,英国商学院校友的平均薪资仍低于与法国商学院校友,分别为5.5万美元和6.4万美元。
陈宇说:“一些互联网行业的天才创造了很多奇迹,但这并不代表一切。每个行业都有各自的规则。在你在这一行业开始之前,你必须要知道如何生产产品,如何销售,如何经营一家公司。我们不能期待一个刚刚毕业的大学生一开始就知道这些经验。”
Guo Jingjing's alleged romance with Kenneth Fok, the grandson of late Hong Kong tycoon Henry Fok, has captured the imagination of a country that seems to have become as interested in the private lives of its athletes as in their athletic performances.
If 2017 was the year of fake news, 2018 is shaping up to be one of fake data. And just as fake news comes in many varieties — real news dubbed by the US president as fake, as well as nonsense gaining huge audiences on social media — so does fake data.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

这位设计师晚年最重要的伙伴之一就是他的伯曼猫邱佩特,拉格菲尔德称它为他唯一的真爱,而且他还曾说过,如果(与动物结婚)合法的话,他会与邱佩特结婚。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 北京新机场人才公租房明年投用
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

The TV drama is not based on a novel but the story of a real businesswoman Zhou Ying. Born in the Qing Dynasty (1644-1911), Zhou was the richest female entrepreneur in Shaanxi province at that time.
If the user set up a truthful answer, according to statistics provided by the researchers, in 19.7% of the cases, an attacker would need a single try to guess the correct answer to the question "What is your favorite food?" in the case of American users.
improvement

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 世界最大直径高钢级弯管试制成功
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

007系列电影荣誉主题曲之二:凯蒂·朗--《屈服》
纽约人向专栏提出的问题,不仅取决于他们的个人情况,还取决于当今的重大问题,比如住房成本上升、士绅化、豆腐渣工程。最终,2014年成为了一个一切都在增长的年份,增长的包括房价、租金,以及最重要的——楼盘数量。根据纽约房地产委员会(Real Estate Board of New York)的数据,10月批准建设的单元达到了16700套。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

此外,这也是北京大学连续第二年在亚洲大学排行榜上排名第二位。
不像那些狂热追星的小女孩,玛蒂认为她一直都能保持着冷静的头脑,即使在格莱美颁奖典礼这种场合。因为她将自己视为一个明星,所以她需要表现得体。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Followers are also getting younger and better educated, with 77.8 percent in the 17-to-33 age group and 75 percent with a higher education.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 重庆再出“组合拳”打击炒房
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

自从该调查首次面世以来,香港已经连续第七年高居榜首了。
皮耶里在大型消费类产品公司工作过多年,如Stride Rite和科迪斯(Keds)等。所以,这种夫妻店在推出新产品时所遇到的困难令皮耶里感到失望。她解释道:“越创新的产品,因为与主流和‘已知’相悖,因而越难销售。”因此,她在五年前成立了The Grommet,这个信息分享平台会将消费者与发明者的故事和产品联系起来。皮耶里的公司帮助发布的产品包括自制碳酸饮料机Sodastream和智能腕带Fitbit。她一直把惠普公司(HP)CEO梅格惠特曼作为自己的导师,并在哈佛商学院(Harvard Business School)担任入驻企业家。
还有仅仅9所商学院参与了所有4项排名。它们的排名从第三(西班牙企业商学院)到第38位(米兰理工大学MIP管理学院(Politecnico di Milano School of Management))不等。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: “互联网+“ 时代下的石材行业
Paper

Length-scale dependence of protein hydration-shell density

conservative
《量子破碎》
May the beauty and joy of New Year remain with you throughout the new year!愿新春美景与欢乐常伴随你!
limited

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 艺术涂料究竟是什么?
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

3.解决问题的好手
As for Dirk, nobody should ever go out the way they do, but it happens all the time. In some ways, maybe it's easier if the reckoning is this painful.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

节目25 歌曲《风吹麦浪》,李健 孙俪
下面就是今年汽车业所经历的高峰和低谷:
周二在上海举办的中国国际机器人产业发展高峰论坛称,2017年,工业机器人的销量和增速均创新高。在这些工业机器人当中,有37825台为国产制造,同比增长29.8%。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

凯莎与死亡金属之鹰乐队联合创作了《Let‘Em Talk》(《让他们说去吧》)这首流行朋克风格的歌曲,它以吉他原声为主导,是一首能够瞬间引爆全场的经典之作。
吊床架组装方便,可以架在桨板、橡皮船和皮筏上。

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